DHPS: Dihydropteroate Synthase (DHPS) is an essential enzyme for the synthesis of Dihydropteroate in bacteria, and DHPS is absent in the humans. The folp1 gene (ML0224) encodes DHPS in Mycobacterium leprae and mutations within folp1 gene are associated with resistance to dapsone, a bacteriostatic drug in the multi-drug therapy for leprosy. The mutations that are included in the HARP database are only the missense mutations represented by amino acid substitutions at each residue position in the DHPS structure. Structural impacts of all the 19 possible substitutions at each residue position are computed using various predictive algorithms. Please see the HELP page for more information. Submit either single mutations or just the residue positions in the fields below. Additionally, user can upload Ab1 chromatogram files and view results of the BlastX search.
Note: Query mutations and residue positions here. Please see the help page for more information.
3D Visualization of the Dapsone Binding Site in DHPS & Chemical structure of Dapsone
Note: Hold left mouse button and hover over the viewers to visualize the structures in 3D. Scroll to zoom.