Last updated on September 22, 2020

HARP - A Web Resource for Predicted Structural Impacts of Anti-microbial Resistance Mutations in Leprosy

HARP (a database of Hansen's Disease Antimicrobial Resistance Profiles) is an integrated web-resource with predicted structural implications of systematic mis-sense mutations in known drug targets of Mycobacterium leprae. A web database of computationally inferred sequence and structure based predictions of stability and vibrational entropy changes due to mutations. A resource to inform the impacts of known and emerging mutations on protein-protein, protein-ligand and protein-nucleic acid affinities, and consequent anti-microbial resistance outcomes in leprosy. HARP is developed with the aim of supporting mycobacterial research community with essential knowledge on the structural implications of mutations conferring antimicrobial resistance in leprosy.

Predicted Impacts of Systematic Missense Mutations in Drug Targets


A bacteriostatic drug that interacts with Dihydroptheroate Synthase (DHPS)


A bactericidal drug that interacts with RNA Polymerase (RNAP)


A bactericidal drug that interacts with DNA Gyrase (GYR)

HARP is a Leprosy Resource

This material is Open Knowledge